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November 21, 1977

Psychopharmacology: A Biochemical and Behavioral Approach

JAMA. 1977;238(21):2309-2310. doi:10.1001/jama.1977.03280220077036

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


A quarter century has passed since modern psychopharmacology was inaugurated by the advent of chlorpromazine and reserpine. During this time the number of psychoactive drugs has escalated annually, and the clinical and research literature on psychopharmacology has increased exponentially. Thousands of papers have been published on neuropharmacology (drug-neurochemical interactions), behavioral pharmacology (drug-behavior interactions), and clinical psychopharmacology (effectiveness and toxicity of drugs in humans). This has created a need for an authoritative, concise, but comprehensive review of the experimental literature, a need amply fulfilled by this well-written volume. The contents are restricted to basic biochemical, behavioral, and neuropharmacologic data obtained from animal studies of psychomotor stimulants, antidepressants, antianxiety agents, antipsychotics, analgesics, and hallucinogens. Lithium is the only important psychoactive drug omitted.

This book consists of three sections. The first covers behavior methods for assessing drug action, and pharmacologic and biochemical methods in psychopharmacology. The second section is devoted to the pharmacologic