[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
September 28, 1970

Alterations in Serum Enzymes in Chronic Renal Failure

Author Affiliations

From the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston. Dr. Katz was a fellow of the Massachusetts Heart Association; he is now with the University of Chicago Medical School.

JAMA. 1970;213(13):2263-2265. doi:10.1001/jama.1970.03170390053014

Serum lactic dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), and amylase levels were determined in 76 chronically uremic patients. Serum LDH was increased in 77% of 486 determinations, and only 10% of the abnormal levels could be accounted for by pathological conditions known to increase LDH. Serum GOT levels were generally normal. Serum amylase was increased in 32% of 175 determinations. There is a high incidence of abnormal LDH and amylase levels in uremic patients. We caution against overinterpretation of these findings and the costly and often unnecessary search for their significance.