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Article
September 28, 1970

Alterations in Serum Enzymes in Chronic Renal Failure

Author Affiliations

From the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston. Dr. Katz was a fellow of the Massachusetts Heart Association; he is now with the University of Chicago Medical School.

JAMA. 1970;213(13):2263-2265. doi:10.1001/jama.1970.03170390053014
Abstract

Serum lactic dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT), and amylase levels were determined in 76 chronically uremic patients. Serum LDH was increased in 77% of 486 determinations, and only 10% of the abnormal levels could be accounted for by pathological conditions known to increase LDH. Serum GOT levels were generally normal. Serum amylase was increased in 32% of 175 determinations. There is a high incidence of abnormal LDH and amylase levels in uremic patients. We caution against overinterpretation of these findings and the costly and often unnecessary search for their significance.

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