Thirty-three patients with carcinoma of the breast had routine bone scans performed with Tc-labeled 1-hydroxy-ethylidene-1,1-disodium phosphonate. Twenty-four of these patients had increased radioactivity in the clinically normal breast in addition to the abnormal breast, if present. Only 2 of the 17 patients studied who had no carcinoma of the breast had bilateral uptake. Both of these had bilateral fibrocystic disease. No patient with two normal breasts had increased uptake in either breast. Of those patients who had uptake in the clinically normal breast, 93% (24/26) had carcinoma.
(JAMA 229:1769-1771, 1974)
Siegel ME, Friedman BH, Wagner HN. A New Approach to Breast Cancer: Breast Uptake of 99mTc-HEDSPA. JAMA. 1974;229(13):1769–1771. doi:10.1001/jama.1974.03230510043020
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