[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
September 23, 1974

A New Approach to Breast Cancer: Breast Uptake of 99mTc-HEDSPA

Author Affiliations

From the divisions of nuclear medicine and radiation health, the Johns Hopkins Medical Institutions, Baltimore.

JAMA. 1974;229(13):1769-1771. doi:10.1001/jama.1974.03230510043020

Thirty-three patients with carcinoma of the breast had routine bone scans performed with Tc-labeled 1-hydroxy-ethylidene-1,1-disodium phosphonate. Twenty-four of these patients had increased radioactivity in the clinically normal breast in addition to the abnormal breast, if present. Only 2 of the 17 patients studied who had no carcinoma of the breast had bilateral uptake. Both of these had bilateral fibrocystic disease. No patient with two normal breasts had increased uptake in either breast. Of those patients who had uptake in the clinically normal breast, 93% (24/26) had carcinoma.

(JAMA 229:1769-1771, 1974)