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September 30, 1974

Atropine Pupils

Author Affiliations

Endicott, NY

JAMA. 1974;229(14):1864. doi:10.1001/jama.1974.03230520011006

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To the Editor.—  Another cause of this finding can be the belladonna alkaloids found in some perfumes.A colleague phoned to tell me that his wife had splashed some perfume in her eye and was complaining of discomfort and blurred vision. She had a dilated fixed pupil that took several days to return to normal.In order to differentiate between the mydriasis from anticholinergic agents and pathologic mydriasis, one can instill a drop of 1% pilocarpine into the affected eye. In anticholinergic-induced mydriasis, there will be little or no change in pupil size, while in the case of pathologic mydriasis, excepting that resulting from glaucoma or ocular trauma, there will be prompt myosis in response to the pilocarpine instillation.