To the Editor.—
Care should be taken in using the "Estrogen Receptor Assay in the Differential Diagnosis of Adenocarcinomas," as proposed by David T. Kiang, MD, PhD, and B. J. Kennedy, MD (238:32, 1977). Stating that estrogen receptor of the 8S type was found only in adenocarcinoma of the breast, uterus, and ovary, they suggested that that fact could be used to evaluate cancers of unknown origin in female patients. However, they examined only a limited number of tissues other than breast.We have also analyzed neoplastic tissues from sites other than the breast for estrogen receptors. The Table summarizes our data. Both the dextrancoated charcoal1 and the sucrose gradient2 methods were used. Tissues were considered positive for estrogen receptors only if they bound at least 6 femtomoles or more of 3H-estradiol per milligram of cytosol protein. We found these percentages of positive tissues: breast, 40%; melanoma, 21%;
Posey LE, Morgan LR, Beazley RM, et al. Estrogen Receptors. JAMA. 1977;238(24):2599. doi:10.1001/jama.1977.03280250025010
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