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October 12, 1970

Primary Biliary Cirrhosis: Prompt Relief of Pruritus With Azathioprine Treatment

Author Affiliations

From the Immunology Laboratory and the departments of rheumatology and gastroenterology, Instituto Nacional de la Nutricion, Mexico City.

JAMA. 1970;214(2):367-368. doi:10.1001/jama.1970.03180020085019

In five patients with primary biliary cirrhosis relief of previously intractable pruritus occurred in two to seven days after onset of azathioprine treatment. It is unlikely that such relief was due to lowering of bile acid levels in serum or skin, or to immunosuppression.