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December 12, 1977

Estrogen Receptors-Reply

JAMA. 1977;238(24):2599. doi:10.1001/jama.1977.03280250025011

In Reply.—  It is possible, as stated by Posey et al, that 8S estrogen receptors may exist in human renal cell carcinoma, as its presence had previously been reported in hamster renal adenocarcinoma.1 However, more detailed information as to the method of determination of sedimentation coefficients and the exact quantitative level of 8S receptors in the two male patients with renal cell carcinoma should be described. Estrogen receptor studies in human kidney and renal cell carcinoma were previously reported.2,3 The report3 described the presence of 4S receptors (varying from 3.5S to 5.7S) under lowsalt condition in sucrose gradient analysis of renal cell carcinoma from six male patients. The discrepancy of the results from different institutions may reflect the variation of method employed. We are looking forward to reading the detailed report of the findings of Posey et al.We certainly agree that more studies and reports in