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December 12, 1977

Breath Odor After Disulfiram

JAMA. 1977;238(24):2600. doi:10.1001/jama.1977.03280250026015

To the Editor.—  Anent Miller's observation on his patient with the malodorous colostomy related both to dietary indiscretion and to disulfiram (Antabuse) therapy (237:2602, 1977), we also observed a peculiar odor during our studies with disulfiram.1 In five of eight normal subjects receiving the anticoagulant warfarin sodium with and without disulfiram for 14 to 18 days, a peculiar, slightly unpleasant odor to their breath, reminiscent of rotten eggs, developed. We attributed the odor to a metabolic product of disulfiram, perhaps carbon disulfide.2