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September 30, 1974

Chemotaxis and Inflammation

Author Affiliations

University of Texas Medical Branch Galveston

JAMA. 1974;229(14):1926. doi:10.1001/jama.1974.03230520068047

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This relatively small monograph is a concise summation and assessment of many facets of chemotaxis. First is a very readable account of the history, techniques, and basic principles of chemotaxis. The middle of the book deals with classification, molecular and cellular biochemistry, and the responses of chemotactic agents and cells. The last two chapters provide informative accounts of the role of chemotaxis in clinical disorders and the inflammatory reaction.

Each chapter begins with a general account of its contents, with a clear delineation between hypothesis, theory, and fact. For example, Menkin's leucotaxic substance, which has gained wide prominence, is placed in proper perspective as a "mélange of different chemotactic factors produced during injury." Also noteworthy are the 515 references to cited articles and books, one third of which were published after 1969.

This volume is quite useful in giving orientation for the plethora of research reports and hypotheses, often conflicting