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October 7, 1974

Miconazole Treatment for Severe Dermatophytoses

Author Affiliations

From the USAF Medical Center, Keesler Air Force Base, Biloxi, Miss. Dr. Mandy is now at the University of Miami School of Medicine.

JAMA. 1974;230(1):72-75. doi:10.1001/jama.1974.03240010040026

The effect of miconazole nitrate applied topically to problem dermatophyte infections (primarily tinea cruris) was studied in double-blind clinical trials. A 2% cream preparation was compared against its vehicle in 62 men. The miconazole treatment was both clinically and mycologically effective in more than 90% of the active treatment group (vs less than 20% in the placebo control group) with prompt relief of symptoms. More important, there was but a single recurrence of disease in the miconazole group during the month after therapy was stopped.

(JAMA 230:72-75, 1974)