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October 26, 1970

Medical News

JAMA. 1970;214(4):675-686. doi:10.1001/jama.1970.03180040009002

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Studies show nickel could play major metabolic role  Serum nickel elevation in patients after myocardial infarction—as well as the discovery of a nickel-containing protein in rabbit serum—suggest a metabolic role for nickel, but the mechanism remains unclearThe evidence that nickel may have an important role in mammalian physiology is becoming stronger and stronger.Recent developments include:

  • Isolation of a nickel-containing protein in rabbit serum by investigators at the University of Connecticut School of Medicine.

  • Studies by this same group, headed by F. William Sunderman, Jr., MD, that showed substantial elevations of serum nickel in a high percentage of victims of acute myocardial infarction.

  • Similar studies, as yet unpublished, by British investigators at The London Clinic, who found elevated serum nickel in 24 consecutive myocardial infarction patients.

  • Further work by F. H. Nielson, PhD, an agriculture department chemist, who has produced symptoms of nickel deficiency