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October 14, 1974

Plasma Fractionation in the United States: A Review for Clinicians

Author Affiliations

From the Blood Resource Branch, Division of Blood Diseases and Resources, National Heart and Lung Institute, Bethesda, Md.

JAMA. 1974;230(2):247-250. doi:10.1001/jama.1974.03240020037020

The Cohn cold ethanol plasma fractionation system, developed in the late 1940s, is still the basis for plasma fractionation practices in the United States today. Plasma is obtained by plasmapheresis, salvaged from fresh or outdated whole blood, or is extracted from human placentas to produce five types of clinical products of proven efficacy and safety. Despite the recognized advantages and current entrenchment of the Cohn fractionation system and its partial solution of the hepatitis problem, new developments could improve the present practice. Improved salvage of useful proteins from fractions that are currently discarded must be strongly supported.

(JAMA 230:247-250, 1974)