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January 2, 1978

Intrauterine Growth Retardation in Osteogenesis Imperfecta

Author Affiliations

Northwestern University Medical School Chicago
University of Louisville Louisville

JAMA. 1978;239(1):23. doi:10.1001/jama.1978.03280280023006

To the Editor.—  We have obtained data indicating that intrauterine growth retardation is characteristic of osteogenesis imperfecta congenita (OIC) but not osteogenesis imperfecta tarda (OIT). This observation could, if confirmed after additional investigations, prove useful for diagnosis and genetic counseling.Our sample consisted of 31 infants with OIT and 20 with OIC studied at Northwestern University Medical School and the University of Louisville Medical School. The diagnosis of OIC was applied only if an infant showed shortened upper and lower extremities, multiple fractures, bowing of the extremities, blue sclerae, and caput membranaceum at birth. By contrast, all infants with OIT were said to be normal at birth, and none experienced a fracture before 3 months of age.The mean birth weight was 2,625± 117 g (SE) in OIC and 3,259±104 g in OIT. These weights were age-adjusted by use of intrauterine weight charts of Battaglia and Lubchenco.1 A nonparametric