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To the Editor.—
Thioridazine is commonly used on a long-term basis in a dosage of 100 to 800 mg daily for the control of maladaptive behaviors manifested by residents in facilities for the mentally retarded. We have recently noted symptoms of nausea and vomiting in a number of cases if this drug is abruptly stopped altogether or when the resident is placed on a drug holiday. These symptoms occur anywhere between 24 to 48 hours after the last dose of the drug is given. This side effect is not mentioned in the manufacturer's literature and, therefore, is being reported here.
Kumar BB. Thioridazine, Drug Holidays, and Incidence of Vomiting. JAMA. 1978;239(1):25. doi:10.1001/jama.1978.03280280025013
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