Previous studies of the effects of diazepam (Valium) on human chromosomes have given conflicting results. To resolve this problem, chromosome analysis was done on the peripheral blood of 20 healthy young adults, sampled both before and after a single 12- to 20-mg intravenous dose of diazepam. All subjects were oral surgery research patients of the National Institute of Dental Research. The mean percentages of chromosomal aberrations per person showed no significant increase during the immediate and sevenday period after use of the drug. While the experimental design of the study was complicated by the use of other drugs to control pain, it could be concluded that no genetic damage as measured by chromosomal analysis was detected following a single therapeutic dose of diazepam.
(JAMA 230:414-417, 1974)
White BJ, Driscoll EJ, Tjio J, Smilack ZH. Chromosomal Aberration Rates and Intravenously Given Diazepam: A Negative Study. JAMA. 1974;230(3):414–417. doi:10.1001/jama.1974.03240030032021
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