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October 28, 1974

Familial Hodgkin Disease

Author Affiliations

Howard University College of Medicine Washington, DC

JAMA. 1974;230(4):536. doi:10.1001/jama.1974.03240040014004

To the Editor.—  Approximately 100 cases of familial Hodgkin disease are recorded in the literature. None showed any distinctive clinical or pathological features.1 No multiplecase family with Hodgkin disease has been described in blacks, as far as it can be ascertained. This report describes the almost simultaneous occurrence of Hodgkin disease in two black brothers. Both developed nodular sclerosing Hodgkin disease of the right inguinal lymph nodes.

Report of Cases.—Case 1.—  This 24-year-old black man was first seen in 1971 because of inguinal lymph node enlargement on the right side. Biopsy yielded a diagnosis of reactive hyperplasia. Three years later, in May 1974, an enlarged 7×4-cm mass, occurring at the same site, was diagnosed as nodular sclerosing Hodgkin disease, from a biopsy specimen. The patient is employed by a construction firm as a journeyman. Both parents are alive; his mother has hypertension. Physical examination, apart from the