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October 28, 1974

Steroid Combinations in Treatment of Trichinosis

Author Affiliations

Rahway, NJ

JAMA. 1974;230(4):537. doi:10.1001/jama.1974.03240040015006

To the Editor.—  A recent editorial (228:735, 1974) pointed out that in the treatment of clinical trichinosis, "corticosteroids should always be given in conjunction with thiabendazole."1 On the other hand, it has been alleged that hydrocortisone antagonizes the action of thiabendazole in the muscle phase of trichinosis in mice. Corticosteroids and thiabendazole are virtually the only drugs used in treating the muscle phase of trichinosis in man, yet there has been very little discussion of whether they should be used concurrently. (During the intestinal phase, corticosteroids would clearly be contraindicated unless accompanied by thiabendazole or other chemosterilizing drugs.)An unpublished trial in this laboratory in 1964 suggested that hydrocortisone did not interfere with the action of thiabendazole against trichinosis in mice. In recent studies, we have reexamined the effects of combination therapy with these drugs. To allow the possible demonstration of either antagonistic or potentiating effects of the steroid, the