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January 30, 1978

Nitroprusside Therapy for a Patient With a Pheochromocytoma

JAMA. 1978;239(5):427-428. doi:10.1001/jama.1978.03280320043018

WE DESCRIBE a patient in hypertensive crisis from a pheochromocytoma, in whom sodium nitroprusside was used without adrenergic blockers, and subsequently was administered for a one-week period in conjunction with blockers to achieve preoperative and ultimately intraoperative blood pressure control. We believe this represents the most extensive experience with this drug in one patient with this condition.

Report of a Case  A 32-year-old woman was transferred to the George Washington University Hospital Intensive Care Unit from another hospital, with uncontrolled hypertension six hours after cesarean section. The patient had a history of labile hypertension and diet-controlled diabetes. She was hypertensive during her first pregnancy, miscarrying at six months.During the current pregnancy, blood pressure became 140/90 mm Hg, and occasional flushing, pedal edema, and proteinuria occurred. At 32 weeks, she was admitted with a blood pressure of 220/140 mm Hg, unchanged by diazepam and bed rest. Despite methyldopa therapy, 500