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November 11, 1974

Hepatitis B in Plasma Fractionation Workers: A Seroepidemiologic Study

Author Affiliations

From the US Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, Cincinnati (Drs. Taylor and Shmunes) and the Department of Hepatology, the Rush Presbyterian St. Luke's Medical Center, Chicago (Dr. Holmes). Dr. Taylor is now with the Department of Dermatology, Cleveland Clinic, Cleveland. Dr. Shmunes is now with the Columbia Skin Clinic, Columbia, SC.

JAMA. 1974;230(6):850-853. doi:10.1001/jama.1974.03240060020022

Between 1968 and 1971, hepatitis B occurred at a plasma fractionation company in 14 employees who had worked in the plasma fractionation area for 18 months or less. Work histories incriminated the early stages of plasma processing as the areas of highest risk. Serologic study at one point (November 1971) showed three individuals with titers positive for hepatitis B antigen (HB Ag), for a total of 1.92% of the 155 workers at risk and from whom blood was drawn. An antibody titer to hepatitis B antigen (anti-HBs) of 1:4 or greater was present in 55% to 92% of those workers who had varying degrees of contact with plasma fractionation. The degree of contact correlated directly with the prevalence of antibody in the populations studied.

(JAMA 230:850-853, 1974)