Between 1968 and 1971, hepatitis B occurred at a plasma fractionation company in 14 employees who had worked in the plasma fractionation area for 18 months or less. Work histories incriminated the early stages of plasma processing as the areas of highest risk. Serologic study at one point (November 1971) showed three individuals with titers positive for hepatitis B antigen (HB Ag), for a total of 1.92% of the 155 workers at risk and from whom blood was drawn. An antibody titer to hepatitis B antigen (anti-HBs) of 1:4 or greater was present in 55% to 92% of those workers who had varying degrees of contact with plasma fractionation. The degree of contact correlated directly with the prevalence of antibody in the populations studied.
(JAMA 230:850-853, 1974)
Taylor JS, Shmunes E, Holmes AW. Hepatitis B in Plasma Fractionation Workers: A Seroepidemiologic Study. JAMA. 1974;230(6):850–853. doi:10.1001/jama.1974.03240060020022
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