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November 18, 1974

Leukopheresis Therapy of a Hypereosinophilic Disorder

Author Affiliations

From the Department of Medicine, Massachusetts General Hospital (Drs. Ellman and Miller), and The Department of Medicine, Peter Bent Brigham Hospital and Children's Hospital Medical Center (Dr. Rappeport), Boston. Dr. Rappeport is a junior faculty fellow of the American Cancer Society.

JAMA. 1974;230(7):1004-1005. doi:10.1001/jama.1974.03240070038024

A young woman developed myositis, myocarditis, and vasculitis associated with severe eosinophilia following the use of sulfisoxazole (Gantrisin). Her illness was not altered by corticosteroid therapy and appeared to be progressive. Following leukopheresis and removal of large numbers of eosinophils on a continuous flow cell separator, there was a prompt decrease in the eosinophilia and rapid clinical improvement. Although the mechanism of this effect is unknown, leukopheresis may be a worthwhile modality of therapy in other patients with progressive hypereosinophilic disorders.

(JAMA 230:1004-1005, 1974)