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February 6, 1978

Handbook of Physiology: A Critical, Comprehensive Presentation of Physiological Knowledge and Concepts, section 1: The Nervous System, vol 1: Cellular Biology of Neurons

Author Affiliations

Medical Center Hospital of Vermont Burlington

JAMA. 1978;239(6):548-549. doi:10.1001/jama.1978.03280330080045

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Eighteen years have past since the section on the CNS in the Handbook of Physiology was published. The first two volumes dealing with the CNS have now appeared under the title of Cellular Biology of Neurons. This choice in itself reflects the growth of knowledge of neurophysiology as well as its extension into new realms that could certainly not have been predicted. The roster of contributors guarantees the quality of contents.

These volumes clearly bear witness to the truly amazing discoveries that have been made possible by the introduction of a large number of new investigative techniques such as electron microscopy, freeze-fracture methods, tissue culture, tetrodotoxin-binding, and intracellular recording. While the previous emphasis on the biophysics of excitable membranes has not been lost, advances in the study of ultrastructure, biochemistry, and the pharmacology of neurotransmitters have considerably broadened the scope of what will undoubtedly become as much of a classic