The presence of signs of systemic sepsis, positive blood cultures, and signs of local inflammation over a cannulated vein that fail to respond rapidly to removal of the cannula and appropriate antibiotic therapy should lead to a suspected diagnosis of septic thrombophlebitis. Surgical exploration and, if the diagnosis is proven, interruption or resection of such a vein should be undertaken to avoid potentially life-threatening complications.
(JAMA 230:1010-1011, 1974)
Munster AM. Septic Thrombophlebitis: A Surgical Disorder. JAMA. 1974;230(7):1010–1011. doi:10.1001/jama.1974.03240070044027
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