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November 18, 1974

Lowered Aortic Impedance as Therapy for Severe Mitral Regurgitation

Author Affiliations

From the C. V. Richardson Cardiac Catheterization Laboratory and the Department of Medicine, University of North Carolina School of Medicine, Chapel Hill.

JAMA. 1974;230(7):1011-1013. doi:10.1001/jama.1974.03240070045028

Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation.

(JAMA 230:1011-1013, 1974)