Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation.
(JAMA 230:1011-1013, 1974)
Grossman W, Harshaw CW, Munro AB, Becker L, McLaurin LP. Lowered Aortic Impedance as Therapy for Severe Mitral Regurgitation. JAMA. 1974;230(7):1011–1013. doi:10.1001/jama.1974.03240070045028
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: