To the Editor.—
We are referring to the recent article "Photodye Herpes Therapy—Cassandra Confirmed?" by Berger and Papa (238:133-134, 1977).A similar patient with multiple papules on the penis, with histologic features of squamous-cell carcinoma in situ, was recently reported by Kopf and Bart.1 This patient also had photochemotherapy for herpes simplex prior to the development of bowenoid papules of the penis. We will soon publish our experience with 11 young men who have multiple lesions of squamous-cell carcinoma in situ on the penis. Of great importance is the fact that only three of the 11 patients received photodye treatments. Therefore, photochemotherapy is not related to this penile condition in most cases if, indeed, it is in any.
Kopf AW, Ackerman AB, Wade T, Bart RS. Photodye Herpes Therapy. JAMA. 1978;239(7):615. doi:10.1001/jama.1978.03280340035011
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