To the Editor.—
We have recently observed that the frequency of occurrence of a particular second sublocus group HL-A antigen (tentatively specified by us as J-1-1) was significantly higher (P <.001) in Japanese patients with thromboangiitis obliterans (TAO) than it was in a population of normal Japanese. As shown in the Table, J-1-1 antigen was found in 46% of the TAO patients, relative to a normal population occurrence of 18%.Also, antigens HL-A9 and W10 showed an increased occurrence in TAO patients. However, antigen HL-A12 was not found in TAO patients, but it occurred with a frequency of 20% in the normal population.The Figure illustrates our classification of the J-1-1 antigen.In our study, 11 antisera from pregnant Japanese women showed a very high correlation with each other in their reactivities on the lymphocytotoxicity test (LCT), using normal Japanese panel lymphocytes. With the LCT test antisera, the antigen that
Ohtawa T, Juji T, Kawano N, Mishima Y, TOHYAMA H, ISHIKAWA K. HL-A Antigens in Thromboangiitis Obliterans. JAMA. 1974;230(8):1128. doi:10.1001/jama.1974.03240080018015
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