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November 25, 1974

Group B Streptococcal Infections in Infants: The Importance of the Various Serotypes

Author Affiliations

From the Department of Pediatrics, Baylor College of Medicine, Houston. Dr. Baker is now with Channing Laboratory, Harvard Medical School, Boston.

JAMA. 1974;230(8):1158-1160. doi:10.1001/jama.1974.03240080040025

Group B streptococci produce two types of illness in infants, according to age at onset. Serotyping of isolates collected during a 3 1/2-year period was performed to define the relationship between type of illness caused by group B streptococci and specific serotype. Type III isolates were significantly increased among infants with meningitis of either the "early-" (80%) or "late-" (93%) onset types when compared to asymptomatically colonized neonates (36%) and neonates with early-onset septicemia without meningitis (33%). These findings suggest that type III strains may possess invasive properties that allow meningeal penetration, that there are epidemiologic peculiarities in the acquisition of late-onset infections, or both.

(JAMA 230:1158-1160, 1974)