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February 20, 1978

Precursor Lesions in Familial Melanoma: A New Genetic Preneoplastic Syndrome

Author Affiliations

From the Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Md (Drs Reimer, Greene, and Fraumeni); the Department of Hematology-Oncology, Cleveland Clinic Foundation, Cleveland (Dr Reimer); and the Department of Pathology, Dermatology, and Fels Research Institute, Temple University School of Medicine, Philadelphia (Mr Clark and Dr Ainsworth).

JAMA. 1978;239(8):744-746. doi:10.1001/jama.1978.03280350068019

In seven consecutive melanoma-prone families, pigmented lesions with distinctive clinical and histologic characteristics occurred in 18 of 20 melanoma patients (90%) and 24 of 43 first-degree relatives (56%). Recognition of these lesions led to the detection of early-stage melanoma in six family members. This syndrome appears to represent an autosomal dominant trait and may serve as a cutaneous marker to identify persons at high risk for melanoma.

(JAMA 239:744-746, 1978)