Silver sulfadiazine is a new topical antimicrobial agent that is used effectively to prevent and treat sepsis in patients with second- and third-degree burns. Because of its low toxicity, relative freedom from complications, and wide spectrum of antimicrobial activity, silver sulfadiazine represents an advance in the pharmacologic management of the burned patient.
(JAMA 230:1184-1185, 1974)
Ballin JC. Evaluation of a New Topical Agent for Burn TherapySilver Sulfadiazine (Silvadene). JAMA. 1974;230(8):1184–1185. doi:10.1001/jama.1974.03240080064038
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