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December 2, 1974

The UGDP Study

Author Affiliations

Summit, NJ

JAMA. 1974;230(9):1256-1257. doi:10.1001/jama.1974.03240090016011

To the Editor.—  As support for the University Group Diabetes Program (UGDP), Dr. Clayman (228:1523, 1974) cited Soler et al,1 although he acknowledges defects in their retrospective study.Soler et al reviewed the records of 184 diabetics with confirmed acute myocardial infarction admitted to a coronary care unit (CCU) in England from 1967 to 1973. Oral hypoglycemic therapy was discontinued on admission and, unless diabetic control was satisfactory on diet alone, insulin was used. Patients were grouped according to diabetic therapy at the time of myocardial infarction, and subsequent events were attributed to the effects of such treatment.The article discussed the incidence of primary ventricular fibrillation and fatalities while patients were still in the CCU, but did not provide the individual patient data necessary to make valid judgments about the effects of treatment. Eleven of the 15 patients who developed ventricular fibrillation while in the CCU did so within