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December 9, 1974

Medical News

JAMA. 1974;230(10):1365-1379. doi:10.1001/jama.1974.03240100003001

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Osteosarcoma may respond to treatment with sex hormones  A close look at a tragic adolescent disease has led to hopes that osteosarcoma may join renal cell carcinoma, breast carcinoma, and prostatic carcinoma in the list of hormone-responsive tumors.Indeed, on the basis of their findings, orthopedic surgeons James H. McMaster, MD, and Pierce E. Scranton, MD, of the University of Pittsburgh School of Medicine believe "it is time for a national cooperative study to evaluate hormone therapy in osteosarcoma."The two investigators were first provoked by their review of 20 years' experience with osteosarcoma at the University of Pittsburgh. The review showed—not unexpectedly—that the patients were predominantly male, that the tumor had a tendency to occur in the metaphysis of rapidly growing bones and that most of the patients were growing adolescents. (Dr. C. H. G. Price in England had previously found that the peak incidence of the tumor