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December 14, 1970


JAMA. 1970;214(11):2059. doi:10.1001/jama.1970.03180110067023

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To the Editor.—  It is certainly true that patients with Parkinson's disease whose mobility has been restored with treatment may retain some postural instability and should be cautioned about the potential risks of greater physical activity. However, we believe that the value of increased mobility far outweighs the risk of fracture or cardiovascular failure.A significant number of mental side effects are clearly related to the ingestion of levodopa. Other mental reactions seem to be related more clearly to other phenomenon including the age of the patient, the severity of Parkinson's disease, the concomitant use of other medications, and the degree of dementia. In our series those patients with dementia or severe Parkinson's disease and those in the older age group are most likely to develop mentation disturbances on levodopa. It is a generally accepted observation that patients with advanced generalized brain disease are quite susceptible to the development of