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December 9, 1974

Mebendazole: Treatment of Trichuriasis and Ascariasis in Bahamian Children

Author Affiliations

From the Georgetown University Medical School, Washington, DC, and the Hardecker Children's Clinic and Agnes Hardecker Research Laboratory, Nassau, Bahamas (Dr. Wershing).

JAMA. 1974;230(10):1408-1411. doi:10.1001/jama.1974.03240100026021

Mebendazole (Vermox), a new broad-spectrum anthelminthic, was used in 107 Bahamian children with trichuriasis, 88 of whom had concomitant ascariasis, in a dose of 100 mg twice daily for three days. After treatment, three consecutive daily formalin-ether determinations and stool egg counts by the Stoll method were performed. Egg reduction rates of 97.6% and 99.5% were obtained for Trichuris trichiura and Ascaris lumbricoides, respectively. Respective cure rates were 68.2% and 98.8%. Drug tolerance was excellent and side effects were nil. Mebendazole was confirmed as a safe and easily administered broad-spectrum anthelminthic, particularly useful in trichuriasis.

(JAMA 230:1408-1411, 1974)