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December 9, 1974

Recent Advances on Pain: Pathophysiology and Clinical Aspects

Author Affiliations

Chicago Medical School Chicago

JAMA. 1974;230(10):1448-1449. doi:10.1001/jama.1974.03240100064039

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This monograph includes 13 excellent papers presented at an international symposium in Florence, Italy, in 1972. The first six chapters concern physiology, pharmacology, and the measurement of pain. They adequately review already established concepts of the mechanisms of pain and bring the reader up to date on recent progress. Sicuteri's discussion of vasoneuractive substances and their relationship to both cardiac and head pain makes a complicated subject readily understandable for both the clinician and researcher. His successful treatment of migraine with serotonin precursors may constitute a significant breakthrough in migraine therapy.

In the clinical portion of the book, Dr. Houde's discussion of average and optimal doses as well as placebo therapy will give the clinician new understanding and insight in treating the pain of cancer. The discussion of the proper application of analgesic block for intractable pain should reawaken interest in this important subject. However, I question the author's use