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December 16, 1974

Staphylococcal Susceptibility To Penicillin G

Author Affiliations

Charleston Area Medical Center Charleston, WVa

JAMA. 1974;230(11):1512. doi:10.1001/jama.1974.03240110016006

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To the Editor.—  The recent report by Ross et al (229:1075, 1974), concerning changing susceptibility patterns to Staphylococcus aureus, prompted a review of cultures in our hospital. Data on 618 S aureus cultures from Dec 1, 1973, through June 30, 1974 (processed by the Kirby-Bauer technique) reinforce their findings. Forty of 333 inpatient isolates (13.5%) were sensitive to penicillin G, whereas 55 of 281 outpatient isolates (24.3%) were sensitive to penicillin G. Thus, of the total isolates, only 18.2% were sensitive to penicillin G.We believe that one of the semisynthetic penicillins should be employed instead of penicillin G in any suspected S aureus infection severe enough to require antibiotics, until sensitivity studies are available.