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March 13, 1978

Treatment of Peripheral Diabetic Neuropathy

Author Affiliations

Fort Wayne, Ind

JAMA. 1978;239(11):1037. doi:10.1001/jama.1978.03280380037010

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To the Editor.—  Davis et al are thanked for their recent BRIEF REPORT on the treatment of peripheral diabetic neuropathy treated with amitriptyline hydrochloride and fluphenazine hydrochloride (238:2291, 1977). It is heartening for those who treat neuritis to see that there is still active thinking regarding an effective treatment. Their article has prompted me to review my experience with the treatment of diabetic neuropathy over the past two years. My files contain some 31 cases treated with combinations of tricyclic antidepressants and neuroleptic agents (antipsychotic agents). My results, using combinations of the tricyclic agents (amitriptyline, imipramine, and doxepin), along with one of the neuroleptic agents (fluphenazine, trifluoperazine, chlorpromazine, thioridazine, haloperidol, or chlorprothixene), has not been so successful. I have tried these agents in varying doses, mainly exceeding those of Davis et al, but without any notable success. I learned about this treatment at a number of meetings, where I found