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To the Editor.—
A recent article entitled "Brown Tumor of the Orbit" by Holzer et al (238:1758,1977) was indeed interesting reading. We have observed a similar phenomenon in a 10-year-old boy who had unilateral exophthalmos and whose condition was initially diagnosed elsewhere as a malignant giant cell tumor of the orbit. Unfortunately, massive radiation therapy was administered to the orbit, and it was not until a year later that elevated serum calcium levels were noted and bone abnormalities detected. Hyperparathyroidism was diagnosed at that point, and a parathyroid adenoma was resected. He has subsequently done well with the exception of the development of a cataract in the eye, which was irradiated. Review of orbit tumor slides indicated the presence of a brown tumor.I bring this second case to the attention of readers to point out that hyperparathyroidism in the young occurs, that it can be manifested as unilateral exophthalmos,
Block MB. Brown Tumor of the Orbit. JAMA. 1978;239(11):1037. doi:10.1001/jama.1978.03280380037012
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