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March 13, 1978

Brown Tumor of the Orbit

Author Affiliations

Phoenix, Ariz

JAMA. 1978;239(11):1037. doi:10.1001/jama.1978.03280380037012

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To the Editor.—  A recent article entitled "Brown Tumor of the Orbit" by Holzer et al (238:1758,1977) was indeed interesting reading. We have observed a similar phenomenon in a 10-year-old boy who had unilateral exophthalmos and whose condition was initially diagnosed elsewhere as a malignant giant cell tumor of the orbit. Unfortunately, massive radiation therapy was administered to the orbit, and it was not until a year later that elevated serum calcium levels were noted and bone abnormalities detected. Hyperparathyroidism was diagnosed at that point, and a parathyroid adenoma was resected. He has subsequently done well with the exception of the development of a cataract in the eye, which was irradiated. Review of orbit tumor slides indicated the presence of a brown tumor.I bring this second case to the attention of readers to point out that hyperparathyroidism in the young occurs, that it can be manifested as unilateral exophthalmos,