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December 16, 1974

A Guide to Drug Therapy in Renal Failure

Author Affiliations

From the Division of Nephrology, Department of Medicine, University of Oregon Medical School, Portland (Dr. Bennett), the Renal-Electrolyte Section, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia (Dr. Singer), and the Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (Dr. Coggins).

JAMA. 1974;230(11):1544-1553. doi:10.1001/jama.1974.03240110036016

Five tables suggest maintenance dosage intervals for common drugs used in patients with renal insufficiency, based on data in the literature. If information about a particular drug is unavailable, emphasis is given to biological half-life, normal pharmacology, and creatinine clearance for modification of the usual dose schedules. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for concurrent dialysis suggested.

(JAMA 230:1544-1553, 1974)