A patient with systemic lupus erythematosus had chills, fever, and headache on four separate occasions after ibuprofen ingestion. One such episode was accompanied by cerebrospinal fluid findings compatible with meningitis. Drug rechallenge under controlled conditions established the relationship between ibuprofen ingestion and meningitis.
(JAMA 239:1062-1064, 1978)
Widener HL, Littman BH. Ibuprofen-Induced Meningitis in Systemic Lupus Erythematosus. JAMA. 1978;239(11):1062–1064. doi:10.1001/jama.1978.03280380062020
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