In 11 patients, loss of postural reflexes was the initial and predominant manifestation of parkinsonism. None of these patients responded to standard anticholinergic medication. All 11 responded dramatically to amantadine or levodopa. It is important to recognize that parkinsonian deficit can manifest itself solely or predominantly as falling. Such patients usually respond well to amantadine or levodopa.
(JAMA 230:1555-1557, 1974)
Klawans HL, Topel JL. Parkinsonism as a Falling Sickness. JAMA. 1974;230(11):1555–1557. doi:10.1001/jama.1974.03240110047018
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: