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December 23, 1974

Levarterenol Irrigation: Control of Massive Gastrointestinal Bleeding in Poor-Risk Patients

Author Affiliations

From the Department of Surgery, Roswell Park Memorial Institute, and the Department of Surgery, State University of New York at Buffalo.

JAMA. 1974;230(12):1653-1657. doi:10.1001/jama.1974.03240120021013

Massive upper gastrointestinal hemorrhage occurred in 12 extremely poor-risk patients with advanced malignant disease. Previous experience in this institution indicated that most patients with similar conditions could be expected to die as a result of an equivalent bleeding episode. Intragastric or intraperitoneal administration of levarterenol bitartrate controlled the acute bleeding episode in 11 of the 12 patients. Rebleeding occurred in five, but was again controlled with levarterenol in three. Permanent control of bleeding was achieved in ten patients. Two of the four who left the hospital alive eventually had surgery. Only two of the 12 patients died as a result of hemorrhage.

(JAMA 230:1653-1657, 1974)