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March 27, 1978

Medical News

JAMA. 1978;239(13):1271-1279. doi:10.1001/jama.1978.03280400011002

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Daily aspirin therapy appears to reduce recurrence of TIAS  Two 325-mg aspirin tablets, taken twice daily after meals, seem to reduce transient ischemic attack (TIA) symptoms in some patients, according to a preliminary report on one part of a multicenter study.The aim of the 37-month (October 1972 to November 1975) prospective controlled trial was to see if aspirin, compared with a placebo, would reduce TIAs and other cerebrovascular problems in patients with carotid artery region symptoms. It is one of at least five studies of drugs with possible antiplatelet action that have been, or are being, carried out.The University of Texas Health Science Center, Houston, was the central registry for this Aspirin In TIA Study (AITIA), in which ten US institutions participated.Some 1,300 people were screened as potential candidates, and 307 volunteers eventually were entered in the study. Therapy was assigned on a random, double-blind basis,