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December 28, 1970

Hyperbaric Oxygen and Its Clinical Value: With Special Emphasis on Biochemical and Cardiovascular Aspects

Author Affiliations

University of Illinois College of Medicine Chicago

JAMA. 1970;214(13):2341-2342. doi:10.1001/jama.1970.03180130073033

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Hyperbaric oxygenation is the exposure of things—usually living things, but at times even in vitro biochemical reaction mixtures—to oxygen at partial pressures greater than those obtainable at one atmosphere. This is usually done in a tank capable of withstanding internal pressures greater than the surrounding atmospheric pressure. Such tanks may be small enough to hold only a few Petri dishes or large enough to house an operating room where an entire surgical team may perform open-heart surgery.

The author reviews the biochemical and physical problems associated with such exposures. He devotes separate chapters to the effects on cerebral, peripheral, portal, and coronary circulations. A separate chapter deals with the use of highpressure oxygen in organ preservation. Meijne reviews the long-recognized and generally accepted use of hyperbaric oxygenation as an important adjunct in the treatment of gas gangrene. The Amsterdam experience of treating 106 cases of gas gangrene with only 19