THE MODERN era of cerebrovascular disease began in 1946 with a landmark paper by Kubik and Adams.1 A description of antecedent symptoms and those of onset as well as of neurological abnormalities of the final illness was provided for each of the 18 patients. The authors did not discuss the possible importance of antecedent symptoms, ie, attacks, in six patients and probable warning symptoms in four others. These episodes are now called transient ischemic (focal cerebral) attacks (TIA).
Review of the Literature
The report of the nitrous oxide method for the quantitative determination of cerebral blood flow in man in 1948 by Kety and Schmidt2 opened an era that has seen the publication of thousands of papers about cerebral blood flow in animals and man. The Kety and Schmidt method, ie, Fick principle, has been modified in a number of ways, particularly with technical improvements, including computer analysis.
Millikan CH. Cerebral Circulation. JAMA. 1978;239(13):1313–1315. doi:10.1001/jama.1978.03280400053020
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