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March 27, 1978

Haemostasis: Biochemistry, Physiology, and Pathology

Author Affiliations

Northwestern University Chicago

JAMA. 1978;239(13):1327-1328. doi:10.1001/jama.1978.03280400067031

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Sweeping advances in our knowledge of the hemostatic mechanism have occurred within the past ten years. Much progress has been made in the areas of platelet biochemistry and physiology, structure-function relationships of individual clotting factors, the initiation of coagulation and fibrinolysis, and the role of coagulation inhibitors. This new knowledge of the basic mechanisms of hemostasis has provided greater insight into the pathophysiology of inherited and acquired coagulation disorders and has led to more rational therapeutic interventions.

Haemostasis: Biochemistry, Physiology, and Pathology, edited by D. Ogston and B. Bennett, is a repository for much of this new information. The book, composed of 26 chapters authored by 24 contributors, focuses predominantly on the biochemistry of the hemostatic constituents (the first 350 pages), and in the last ten chapters deals with pathophysiological relationships. Highlights include a discussion of the surface-mediated initiation of blood coagulation by O. D. Ratnoff, a 60-page description of