Brain scans were performed on patients during the first hour following injection of sodium pertechnetate Tc 99m, and selected patients were rescanned 1 to 24 hours later. Eighty brain tumors were found among nearly 1,500 patients scanned during a two-year period. Diagnoses were established for 74 through histological examination, and for 6, through clinical, scan, and neuroradiological findings. Forty were scanned twice, and in 15 the early scans were normal or equivocal. Fourteen of these 15 had abnormal findings upon rescanning. Twenty-six nondiagnostic to moderately abnormal early scans increased in their degree of abnormality upon rescanning. The detectability of brain tumors improved from 80% with routine early scanning, to 93% with rescanning. The optimal time for repeated scanning is three to four hours following tracer injection.
Gates GF, Dore EK, Taplin GV. Interval Brain Scanning With Sodium Pertechnetate Tc 99m for Tumor Detectability. JAMA. 1971;215(1):85–88. doi:10.1001/jama.1971.03180140049008
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