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To the Editor.—
In my practice of diseases of the chest, I have at least 1,000 patients who use and rely on a pressured aerosol device containing isoproterenol. Depending on the extent of their respiratory embarrassment, they use this device from 1 to 20 times a day. All these patients suffer from asthma, bronchitis, or emphysema and have been shown to have a bronchospastic component to their disease by objective pulmonary function testing in my laboratory.In addition, I have given at least 30,000 consecutive intermittent positive pressure breathing (IPPB) treatments utilizing a pressure aerosol device containing isoproterenol, in line with the stream, without any major or minor side effect or complication. My patients, who own their own IPPB machines at home, have probably given themselves a similar number of treatments utilizing the aerosol device with no complications.
Joannides M. Aerosols and Aerosol Propellants in Asthma. JAMA. 1971;215(1):119. doi:10.1001/jama.1971.03180140082023
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