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January 20, 1975

HL-A Antigens and Sacroiliitis

Author Affiliations

From the departments of medicine and surgery, Denver Veterans Administration Hospital (Dr. Mills and Mr. Arai) and the University of Colorado Medical Center (Drs. Mills and Gupta), Denver.

JAMA. 1975;231(3):268-270. doi:10.1001/jama.1975.03240150030017

The histocompatibility antigen W27 has been found to have a high incidence in ankylosing spondylitis (96%), Reiter syndrome (74%), and other forms of arthritis that may involve the axial skeleton.

In patients with Reiter syndrome, there was no correlation between the presence of W27 antigen and the extent or duration of the symptoms. Sacroiliitis was predominantly found in those patients with W27 antigen in all the axial arthropathies. Tissue-typing techniques may be of value in detecting early or atypical disease.

(JAMA 231:268-270, 1975)