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May 5, 1978

Tetracycline: Another Example of Generic Bioinequivalence

Author Affiliations

From the Department of Pharmacy and Pharmaceutics (Drs Wood and Flora), and Division of Infectious Diseases, Department of Medicine (Dr Duma), Medical College of Virginia Campus of Virginia Commonwealth University, Richmond.

JAMA. 1978;239(18):1874-1876. doi:10.1001/jama.1978.03280450046023

Because of the Food and Drug Administration batch certification assurances, state government systems generally purchase antibiotics from the lowest bidder. A tetracycline hydrochloride tablet purchased in this manner is shown to be inferior to the innovator capsule product.

(JAMA 239:1874-1876, 1978)