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Article
May 5, 1978

Blue Rubber-Bleb Nevus Syndrome

Author Affiliations

From the Division of Gastroenterology, Department of Medicine, University of Miami School of Medicine and Veterans Administration Hospital, Miami.

JAMA. 1978;239(18):1887. doi:10.1001/jama.1978.03280450059029
Abstract

IN 1860, Gascoyen1 reported an association between cutaneous nevi, intestinal lesions, and gastrointestinal (GI) bleeding. Bean2 separated the blue rubber-bleb nevus syndrome (BRBNS) from other cutaneous vascular lesions and gave the syndrome its name. Demonstration of these lesions has been performed by way of angiography, laparotomy, and autopsy. This case is an example of the BRBNS in which the diagnosis of the GI lesion was made by endoscopy.

Report of a Case  A 23-year-old man was well until three weeks before admission, when he noted the onset of melena, weakness, and fatigue. He denied nausea, vomiting, hematemesis, or hematochezia. There was no history of abdominal pain or peptic ulcer disease. He denied aspirin ingestion and admitted to drinking six beers each week.Physical examination revealed pallor. Vital signs were normal except for a resting tachycardia rate. No mucosal lesions were seen. The skin (Figure) demonstrated several blue rubber-bleb

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