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July 24, 1981

First-Trimester Drug Use and Congenital Disorders

JAMA. 1981;246(4):343-346. doi:10.1001/jama.1981.03320040015021

We determined the prevalence of certain major congenital disorders among the infants of women who used a wide variety of drugs during the first trimester of pregnancy in a prepaid health plan in which automated recording of prescriptions filled and disorders diagnosed at birth was available. No strong associations between any of the commonly used drugs and congenital disorders studied were present.

(JAMA 1981;246:343-346)